Cyclosporin A inhibits rDNA transcription in lymphosarcoma P1798 cells.
نویسندگان
چکیده
منابع مشابه
The role of ribonuclease in regression of lymphosarcoma P1798.
RNase activity increases in P1798 lymphoid tumors main tained in BALB/c mi ce that are undergoing irevitro drug-induced regression. Corticosteroids, 5-fluorouracil, vincristine, vinblastine, methotrexate, and triethylenemelamine produce re gression of appropriate sublines of P1798 lymphosarcoma as well as an increase in RNase activity. Numerous other agents tested had no effect either on tumor ...
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Cells of corticoid-sensitive (CS) and corticoid-resistant (CR) lymphosarcoma P1798 were labeled in vivo with either [14C]- or [3H]fucose before and after treatment with 9-alpha-fluoroprednisolone (9-FP). Labeled glycopeptides, derived from isolated, Pronase-digested cell membranes of both tumors were separated by gel filtration on Bio-Gel P-10 by a double-label technique. Elution profiles of CS...
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Two-dimensional gel electrophoresis was used to detect [35S]methionine-labeled newly synthesized proteins from corticosteroid-sensitive and corticosteroid-resistant P1798 mouse lymphosarcoma cells. When the protein patterns from corticosteroid-sensitive cells are compared with those from highly resistant cells, they are very similar except for seven changes. One of the most obvious changes is t...
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The prostaglandin synthase cyclooxygenase-2 (COX-2) is produced by an immediate early response gene induced in most cells by a variety of stimuli. Several studies have shown that the immunosuppressant cyclosporin (CsA) interferes with prostanoid metabolism, but the mechanisms are unclear. Here we examine the effect of CsA on COX-2 mRNA induction in cultured rat vascular smooth muscle cells (VSM...
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BACKGROUND/AIMS Hypoalbuminemia occurs frequently in renal transplant recipients immediately after renal transplantation. We studied the regulation of hepatic albumin synthesis by cyclosporin A (CsA) in Huh7 cells. METHODS Huh7 cells were incubated with various concentrations of CsA for 4, 8, 16, and 24 hours. Albumin was measured in Huh7 cell-conditioned medium by sandwich enzyme-linked immu...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1987
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)47709-5